04 · GLP-1 & Metabolic Weight Loss

PlexusDx vs Sesame

For Semaglutide, PlexusDx advertises the lower starting price: $149/month vs $248/month. For Tirzepatide, PlexusDx advertises the lower starting price: $189/month vs $398/month. Membership is included when billed separately; prices vary by dose and plan length.

Key differences

  • Semaglutide: PlexusDx is lower at $149/month vs $248/month.
  • Tirzepatide: PlexusDx is lower at $189/month vs $398/month.
  • Membership: PlexusDx $0 vs Sesame $99 per month.
PlexusDx vs Sesame
Detail PlexusDx Sesame
Semaglutide $149/month all-in$149/month + membership
Tirzepatide $189/month all-in$299/month + membership
Lowest monthly (incl. membership) $149$248
Membership $0$99
LegitScript Active LegitScript seal on siteNot checked (site blocks automated checks)
Approval Not publishedNot published
Blood work required NoNot published
Shipping Free 2-day shipping (official site)Not published
Extra fees No hidden fees per PlexusDx; charged $0 unless a provider approves medication.Medication paid separately; lab facility fees extra in AZ, HI, ND, NJ, NY, OK, RI, SD and WY.
Data source Checked on provider site (2026-11-10)Checked on provider site (2026-11-11)
Visit PlexusDx → Visit Sesame →

Frequently asked questions

Is PlexusDx or Sesame cheaper?

For Semaglutide, PlexusDx advertises the lower starting price: $149/month vs $248/month. For Tirzepatide, PlexusDx advertises the lower starting price: $189/month vs $398/month. Membership is included when billed separately; prices vary by dose and plan length.

Do PlexusDx and Sesame require blood work?

PlexusDx: not required. Sesame: not published.

How do you get approved at PlexusDx and Sesame?

PlexusDx: not published. Sesame: not published.

Sources

PlexusDx

Sesame

Both columns use the same data as our GLP-1 & Metabolic Weight Loss comparison table. "Not published" means we could not confirm the value. We do not earn a commission from either program. Not medical advice.